Genetic polymorphism in human drug metabolism.
نویسندگان
چکیده
منابع مشابه
Genetic Polymorphism Influencing Arsenic Metabolism in Human
Groundwater pollution by arsenic is a serious worldwide problem, especially in developing Asian and African countries. Large inter-individual variation in the arsenic metabolism has been reported. Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. The M287T polymorphism in AS3MT is considered to be related to inter-individual variation...
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One of the major challenges facing toxicology is to bridge the gap between animal research and risk assessment in man. In this meeting, the genetic polymorphism of drug metabolizing enzymes in relation to drug toxicity will be described.
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Sir: We were interested to read the paper by Armstrong et a1 (1997) on drug-induced movement disorders in relation to the CYP2D6 genotype. We would agree that this important polymorphism may well be a contributory factor in more chronic druginduced movement disorders. G. D. I. Bates Blrm~ngham Children's Hospital. Ladywood M~ddleway, Ladywood, Birmtngham B16 8ET A. E. van Woerkom, 0. Lopes Quee...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1993
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.101.2_69